Shan Goh

Microbes evolve rapidly to survive in challenging environments, including exposure to antimicrobials. The emergence of antibiotic resistance in bacteria, particularly pathogens with potential to infect both humans and animals (e.g. Clostridium difficile, MRSA, Escherichia coli, and Mycobacterium bovis), require investigations into alternative antimicrobials. My research uses gene silencing agents, cationic peptides, and phage as antimicrobials and genetic tools for finding good drug targets, through studying growth essential genes. Related to the control of antibiotic resistance is understanding the transmission of antibiotic resistance genes within bacterial communities. My research is focused on how C. difficile phages contribute to horizontal gene transfer and whether such activities preclude their feasibility as antimicrobials. 

Another antimicrobial strategy is to prime host immune responses using vaccines. Part of my research is on developing subunit vaccines against Theileria lestoquardi and T. parva, which are important protozoan parasites infecting and killing cattle in developing countries.