Cristina Barrero Sicilia

I have got a successful research career in Plant/Crop Science developed in international world-class research centers in Spain, Germany Denmark or the UK, where I just have finished a post-doctoral Research Fellowship in Rothamsted Research (RRes). Starting April-2017), I have been appointed as an Early Career Fellow in System Biology for Food and Disease, joining and supporting both the School of Life and Medical Sciences and the School of Computer Science at University of Hertfordshire. This 5 years post will build on the strengths of both Schools by combining experimental field and lab research with computational modelling.

Most of my research work has been focused in elucidating plant biological mechanisms such as seed development/germination or plant response to abiotic stresses, and transferring the acquired knowledge in model plants to improve traits in agronomic crops. In my early stage research career (2000-2005), working with model plants (such as Arabidopsis, tobacco) and crops (mainly maize and barley), I achieved the molecular characterization of the MYB-R1 transcription factor, now considered as the master regulator of cell differentiation in the transfer cells of the seeds. This outstanding research work was conducted at Alcala University under Dr. Hueros leadership (with several visiting periods at Max Planck Institute in Germany) and was published in five papers. Later (2006-2013), I conceived the system A. thaliana-Brachypodium dystachion-barley that I further developed in Prof. Carbonero’s lab for the study of the DOF and bZIP transcription factor families as regulatory networks operating during seed development, germination and subsequent reserve mobilization. Ten manuscripts have been produced during this period (three of them as senior author). In December 2013 I joined the Lipidomic Group led by Prof. J. Napier at Rothamsted Research (RRes) in a research project focused on unravelling how oil metabolism operates in an extremophile plant, Eutrema salsugineum, that has the traits of oil synthesis and stress tolerance. I play a central role in the project by exploiting the potential of large data set generation in close interaction with disciplines such as molecular biology, bio-imaging and mathematical modelling and computing, to unravel the underlying biochemistry and gene regulation networks, operating during the accumulation of storage oils in extreme environments.

Enhancing Plant Stress Resilience during Germination and Early Seed Development

Linking my expertise in seed development/germination together with an expansion in my knowledge/skills on plant response to abiotic stresses, my research area is focused in advance the understanding in the role of the ABA phytohormone in a scenario of inter-connection between these physiological processes, in both model (Arabidopsis, Brachypodium) and crop species (oilseed rape, wheat, barley). It is widely recognized that the ABA is the major factor implicated in the imposition and maintenance of seed dormancy, preventing germination before the completion of seed maturation and therefore, inhibiting the pre-harvest sprouting (PHS) that leads to a reduction in grain quality, yield and viability, with severe economic consequences. In addition, decades of research focused to elucidate the molecular mechanisms that govern plant adaptive response to adverse environmental condition such as drought, salinity, cold or high temperature, which can reduce average productivity of crops by 50-80%. ABA represents a crucial signal for plant response to such abiotic stresses, leading the adaptive transcriptional response to resist those adverse conditions. Using approaches such quantitative genetics and next-generation sequencing technologies provide new opportunities to identify new genetic components responsible of trait variation.

Along with my research career I have always been committed to undertake research-led teaching and academic activities both as lecturer at the Biotechnology Department of the Universidad Politecnica de Madrid and as a supervisor of undergraduate and postgraduate students, besides PhD fellows. My teaching experience started when I was doing my PhD, at the Cellular and Genetic Dept. of the Universidad de Alcala (UAH), where I collaborate as lab assistant. Afterwards, I could participate as Lecturer in Grade and Post-Grade Programs of Agrobiotecnology at Univ. Politecnica de Madrid (UPM) where, when evaluated, I got over 75% positive ranks. Luckily, I had the honour to supervise the Master Thesis Project of some of the best students in this field, and even better, some of them obtained PhD Fellowship to address the PhD Thesis. Under my supervision, all the students contributed to the publication of high quality research articles, demonstrating a high implication and motivation in the Research.